For some of its route it follows alongside the eastern edge of Primrose Hill park and also includes the commercial centre of the area.
It diverges from Gloucester Avenue at Cecil Sharp House and heads westwards until it meets Primrose Hill.
It runs adjacent to the park and then at the northern end the previously residential buildings give way to shops, restaurants and a pub, the Queen's Hotel, as the road curves eastwards.
Regent's Park Road again meets Gloucester Avenue by the Pembroke Castle pub and then continues over a bridge across the West Coast Main Line until it finishes at the junction with Haverstock Hill between Chalk Farm tube station and the Roundhouse.
There had been an older Chalk Farm Tavern on what is now the street, which was famous as a site of dueling in eighteenth century and Regency London, but was rebuilt in the Victorian era.