She then received commercial success with Routine Love Story (2010), Kedi Billa Killadi Ranga (2013), Power (2014) and Pilla Nuvvu Leni Jeevitham (2014).

Cassandra received praise for portraying a traditional girl in Subramanyam for Sale (2015), a dental student in Jyo Achyutananda (2016), a youngster in Maanagaram (2017), a drug addict in Awe (2018) and a businesswoman in Evaru (2019).

[3] Following her expansion to Hindi films with Ek Ladki Ko Dekha Toh Aisa Laga (2019), she starred in streaming series Rocket Boys (2022) and Jaanbaaz Hindustan Ke (2023).

"[14] After this film, she took time out and went on to graduate in psychology and took another year off before taking a final call on joining movies.

[15][16] Cassandra made her Telugu debut with Shiva Manasulo Shruti opposite Sudheer Babu.

"[27] Her final film of the year was Pilla Nuvvu Leni Jeevitam opposite Sai Dharam Tej, a boxoffice success.

Pranita Jonnalagedda of Times of India noted, "Regina brings freshness to the film with her clean act and is brilliant except when she cries.

She first made her Hindi film debut with Ek Ladki Ko Dekha Toh Aisa Laga opposite Sonam Kapoor.

[40] Bollywood Hungama noted, "Regina Cassandra is quite an important part of the film and impresses with her confident act.

[43] India Today noted, "Regina Cassandra performs extremely well and for a large part of the film, you cannot fathom whether she's guilty or not."

[48] Hindustan Times noted, "Cassandra is incredibly good as Mariam, a role that fits her like a glove.

[52] Cassandra made her web debut with the series Rocket Boys, where she portrayed Mrinalini Sarabhai opposite Ishwak Singh, and reprised her role in the second season.

[53] Saibal Chatterjee of NDTV termed her "terrific", while Roktim Rajpal of India Today noted, "Regina shines despite having limited scope.

[61] Deepa Gehlot of Rediff.com wrote, "Regina Cassandra has an attractive screen presence, but her Kavya is mostly one-dimensional.

[70][71] In her first release of 2025, Cassandra appeared in Vidaamuyarchi, where she played a psychotic gangster opposite Arjun Sarja.

"[73] Avinash Ramachandran opined, "Regena bring in a rather zany vibe to the proceedings and sell her roles with a conviction that is consistent through the film.

[75] Salil Panchal of Forbes noted, "Cassandra has emerged as one of the most dependable and versatile actresses of South Indian cinema.

"[76] Ram Venkat Srikar of The New Indian Express termed her filmography a mix of "conventional and unconventional", and wrote, "Regina exudes much self-awareness" while describing her acting choices.

[78] Mayur Sanap of Rediff.com termed her Hindi debut "unconventional", and said, "Cassandra has successfully carved a niche for herself with her choices of films.

"[5] Sushmita Dey of Times Now noted her for her "versatile roles" and said, "Regina has a unique approach towards every character.

[85] Cassandra is a celebrity endorser for several brands and products such as Kalyan Jewellers, Trends, Biba and Meesho.