She rose to prominence for her role as Brenda Meeks in the comedy horror Scary Movie film series (2000–2006).

And I think when sudden events that are painful happen in your life, you know, they redirect your course," Hall reflected.

"[9] She began a career in the entertainment industry, starting off with a guest appearance on Sadat X's 1996 album Wild Cowboys on the track, "The Interview".

Her television career began with a role on the soap opera Loving, and guest appearances on the Fox police drama New York Undercover.

A year later, she starred in the action-drama Paid in Full, a film directed by Charles Stone III.

From its fall 2010 debut until a series overhaul in January 2011, Regina Hall portrayed Deputy District Attorney Evelyn Price on Law & Order: LA.

Hall felt The Best Man Holiday was different from any sequel she had ever done before since it was not "immediate" and it had been fourteen years since the release of the original.

Mick LaSalle of The San Francisco Chronicle expressed that Hart was "well paired for Hall, who matches him for comedy.

"[19] At the time of the film's release, both Hall and Hart expressed interest in working on other projects together.

[22] In July 2014, it was announced Hall would star in a Lifetime film, entitled With This Ring, with Eve and Jill Scott.

[23][24] In the 2015 film People Place Things, Hall had a major role as the love interest of a newly divorced man.

She played the role of Angie, one of the hair stylists, alongside Ice Cube, Common, and Eve.

In 2018, Hall was part of the ensemble cast of the drama film The Hate U Give, based on the 2017 novel.

Under the pact, Hall will develop and produce television projects via her production company, RH Negative.

Under the agreement, Hall and her team will develop and produce original unscripted true crime, ensemble docuseries and game genres.

When not working in Hollywood, Hall can be found volunteering for the care of senior citizens at a Sherman Oaks, California, convalescent home twice a week as well as raising public awareness for the disease.

[32] In 2010, when she was 40, Hall unsuccessfully tried to become a Catholic nun after a bad break-up, having previously wanted to become one at the age of 14.