Regina High School (RHS) is a Roman Catholic, private, four year college preparatory high school for girls in Warren, Michigan in Metro Detroit.

Located in the Roman Catholic Archdiocese of Detroit, Regina is sponsored by the Sisters of St. Joseph, Third Order of St. Francis.

Regina High School began as a dream of Cardinal Edward Mooney of Detroit.

Each year, the Regina Saddlelites and the Marian Mustangs compete in Powder Puff Football.

The Regina Varsity Softball team, under the leadership of Diane Laffey, have been Division 1 state champs for 4 years in a row.