Maria Regina Sousa (born July 4, 1950) is a Brazilian politician who served as Governor of Piauí between March and December 2022.

A member of the Workers' Party (PT), Sousa previously as Vice Governor from 2019 until her predecessor Wellington Dias' resignation in 2022.

[2] Sousa is a former employee of the Bank of Brazil and served as the secretary of State of Piauí in the first two governments of Wellington Dias.

In October 2017, she voted against maintaining the mandate of Senator Aécio Neves, showing himself favorable to the decision of the First Panel of the Supreme Federal Court in the case where he is accused of corruption and obstruction of justice for requesting R$ 2 million from businessman Joesley Batista.

On December 14, 2018, she resigned as a senator and took on the coalition's second deputy, Zé Santana (MDB) This article about a Brazilian politician is a stub.