[1] Reine (who used the Italian form of her name, Regina) studied voice with Delia Valeri, and with Arthur Lawrason in New York.

[2][3] In 1906, Vicarino performed several small roles in the first season of Oscar Hammerstein I's Manhattan Opera Company.

[4] Vicarino's voice was described as having "all the range and limpidity of an ideal coloratura," in the Los Angeles Herald in 1910; the critic went into further detail, writing that "The upper register is clear and brilliant, and the lower tones are wonderfully vibrant and rich for a coloratura voice.

"[5] She frequently sang the lead role in Donizetti's Lucia di Lammermoor,[6] and she was also considered successful as Violetta in La traviata,[7] and as Micaela in Carmen.

[4] In the 1917-1918 season she toured New England and Canada with the Giuseppe Creatore Grand Opera Company.