It is named after prominent businessman and Baltimore native Reginald F. Lewis.

On April 4, 2008, an art teacher at the Reginald F. Lewis High School, was attacked by one of her students during a regular class.

Footage of the incident was recorded on a phone and was uploaded to the internet.

The case was investigated as possible child abuse by the Baltimore police department and referred to the State's Attorney's office.

The student filed a lawsuit in April 2016 alleging assault.