Reginald Hall Sayre (October 15, 1859 – May 29, 1929) was a prominent American orthopedic surgeon and Olympic sport shooter.

However, his brother Lewis persuaded him to follow the family tradition and enter the Bellevue Hospital Medical College in 1881.

Just seven months after completing his internship, he presented before the New York Academy of Medicine a report on "The Immediate Restoration of Parts to the Normal Position after Tenotomy," where he boldly questioned well-accepted procedures.

[3] He was also consulting surgeon at Hackensack (1891), Hospital for Crippled Children, Newark (1897), Mountainside, Montclair (1898), N. Y.

In 1917, he served as Division Surgeon, with the rank of lieutenant colonel, and during World War I, was in charge of orthopedic instruction to medical officers at the New York University.