Reginald Sheffield was married in 1927 to Louise Van Loon (21 January 1905 – 14 April 1987), a New York-born, Vassar College graduate with a liberal arts education.

The couple had three children: As film production became more and more located in Southern California, Sheffield and his wife travelled back and forth between New York City and Los Angeles.

Being a trained stage actor, Sheffield easily made the transition from silent films to talkies.

He was a working actor who became memorable in numerous character and supporting roles and appeared with some of the greatest film stars of the day, including Constance Bennett, William Powell, George Arliss, Loretta Young, Gary Cooper, Errol Flynn, Rosalind Russell, Cary Grant and Joan Fontaine.

And after his son, Johnny Sheffield, appeared in his last Bomba, the Jungle Boy film in 1955, Reginald created, produced and directed a pilot for a television series, Bantu, the Zebra Boy, but a sponsor was not found and the show was never produced as a weekly series.