It is published by Elsevier on behalf of the International Society of Regulatory Toxicology & Pharmacology.

The current co-editors-in-chief are Lesa L. Aylward and Martin van den Berg.

In 2002, a group of 45 academics wrote a letter accusing the journal of a concealed pro-industry bias, a possible lack of full and independent peer review, and a failure to disclose conflicts of interest, citing a case in which Gio Batta Gori, then-current editor-in-chief, was paid $30,000 by the Tobacco Institute to write an article later published in the journal dismissing the health risks of secondhand smoke.

[1][2] The letter's coordinator later commented that the journal "reads like an industry trade publication, but it's masked as a peer-reviewed journal" and that it lacked any "credible peer-review process.

[1] The journal is abstracted and indexed in EMBASE, EMBiology, and Scopus.