Brignac attended St. Amant High School in Louisiana where he played baseball and football and earned a 3.5 GPA.

He made his professional debut on August 4 with Advanced Rookie Princeton, where in 25 games, he hit .361 with a home run and 25 RBI.

Brignac was Montgomery's shortstop for 2007, where in 133 games and a league-leading (with Emilio Bonifacio) 596 plate appearances, he hit .260 with 17 home runs, 81 RBI.

After the year, he played in the Arizona Fall League with Scottsdale, where he hit .177 (20-113) with two home runs and 6 RBI in 26 games.

[5] He was optioned back to Durham on July 15, 2008,[6] having gone hitless in his first 10 major league at-bats with 1 walk and 5 strikeouts over 4 games.

Brignac began 2009 as Durham's shortstop, where he was hitting .291 in the first month and a half before he earned a promotion to Tampa Bay on May 22.

On September 14, 2009, Brignac hit his first major league home run off of David Hernandez of the Baltimore Orioles.

He finished the game 4-for-4 with three RBIs, a run, a stolen base and a triple shy of hitting for the cycle.

Brignac made the Opening Day roster in 2010 with Tampa Bay as a second baseman and backup shortstop, and stayed there for the whole season.

After an 11-game stint in Durham, he was recalled on August 10 after outfielder Justin Ruggiano was placed on the disabled list.

Brignac began 2012 splitting time with Rodriguez at shortstop, but after hitting .118 in 8 games with the Rays, he was optioned to Durham in favor of Brandon Allen.

Rodriguez was awarded the starting shortstop job, although he eventually relinquished to Johnson and subsequently Ben Zobrist.

[11] Brignac made the Opening Day roster as a backup infielder, and had a pinch-hit single in his Rockies debut.

On November 19, 2013, Brignac signed a minor league deal with the Philadelphia Phillies that included an invitation to spring training.

Before heading to the DL, Brignac hit .258/.329/.409 with five doubles, one triple, one home run, 10 RBI, seven walks, 24 strikeouts and one stolen base in 66 at-bats.

[26] During his tenure with the Astros, Brignac began experimenting as a switch hitter in an effort to prolong his career in the majors.

[33] On January 6, 2022, Brignac was named manager of the Binghamton Rumble Ponies, a Double-A affiliate of the New York Mets.