As the name implies, it runs from Pirihueico Lake to Reigolil Valley.
East of Reigolil-Pirihueico Fault, close or along the Argentina-Chile boundary, are a string of volcanoes pliocene to quaternary volcanoes: Lanín, Pirihueico, Huanquihué, Quelguenco and Chihuío.
Geographically the fault is mostly inside two Chilean communes, Panguipulli and Curarrehue.
Settlements above the fault include the hamlet of Puerto Pirihueico and the town of Curarrehue.
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