In 1849 he became a full professor in succession to Gottfried Hermann, and held this post until his death in Kleinschocher (Leipzig) on 10 August 1870.
Klotz was a man of unwearied industry, and devoted special attention to Latin literature.
1869–1874); Clement of Alexandria (1831–1834); Euripides (1841–1867), in continuation of August Julius Edmund Pflugk's edition, but unfinished; Terence (1838–1840), with the commentaries of Aelius Donatus and Eugraphius [de].
Mention should also be made of Handwörterbuch der lateinischen Sprache (5th ed., 1874); Römische Litteraturgeschichte (1847), of which only the introductory volume appeared; an edition of the treatise Liber de Graecae linguae particulis (1835–1842) of Matthaeus Deverius (or Devares), a learned Corfiote (c. 1500–1570), and corrector of the Greek manuscripts in the Vatican; the posthumous Index Ciceronianus (1872) and Handbuch der lateinischen Stilistik (1874).
[1] With Friedrich Lübker and Ernst Eduard Hudemann, he worked on a Latin dictionary (1847–1857).