Reinhold Lepsius (14 June 1857 – 16 March 1922) was a German painter, especially of portraits, and graphic artist.
He was born in Berlin, the son of Karl Richard Lepsius (1810–1884), professor at the Frederick William University and founder of the Egyptian Museum, and his wife Elisabeth Klein (1828–1899), daughter of the composer Bernhard Klein and great-granddaughter of Friedrich Nicolai.
Reinhold Lepsius was stylistically affiliated with the Berlin Secession school and to some degree with German Impressionism.
Lepsius became known for his portraits of the archaeologist Ernst Curtius, the philosopher Wilhelm Dilthey, and the poet Stefan George who organized literary soirées at his house in Westend.
He was elected a member of the Prussian Academy of Arts in 1916 and also joined the Deutscher Künstlerbund (Association of German Artists).