The organisation is headed by the Indian businessman Anil Ambani.
It runs two major hospitals and multiple medical centres throughout India.
The 150 bed multi-speciality hospital underwent a 'soft' launch in early 2008 for employees and doctors who had accepted offers with KDAH, and became operational in the first week of 2009.
The project was initiated in 1999 by Dr. Nitu Mandke as a large-scale heart hospital.
Reliance Hospital was inaugurated on 8 July 2018 by the then-Maharashtra CM Devendra Fadnavis.