A more plausible motive for the synagogue's origin stems from the Hebrew inscription on the foundation tablet that reads: Husband, Reb Israel, son of Josef of blessed memory, bound in strength, to the glory of the Eternal One, and of his wife Malka, daughter of Eleazar, may her soul be bound up in the portion of life, built this synagogue, the house of the Lord, from her bequest.

The Remah Synagogue was built in Kazimierz, then a suburban village outside Kraków, located on the right bank of the Vistula River, immediately to the south of the Royal Castle on the Wawel Hill.

As it is hard to believe that the construction actually began without the royal permission, the inscription should therefore be understood as possibly referring to the date when the decision to build a second synagogue in Kazimierz was taken by its founder.

During the Holocaust, the synagogue was sequestered by the German Trust Office (Treuhandstelle) and served as a storehouse of firefighting equipment, having been despoiled of its valuable ceremonial objects and historic furbishing, including the bimah.

In 1957, thanks to the efforts of the local Jewish community and of Akiva Kahane, the Joint Distribution Committee representative in Poland, the Remah Synagogue underwent a major restoration that reestablished much of the pre-war appearance of the interior.

[3] The prayer hall features a centrally situated rectangular bimah with a reconstructed wrought-iron enclosure that has two entrances, one displaying an 18th-century polychrome double door coming from a destroyed synagogue outside Kraków.

[3] A ner tamid with the Hebrew inscription "An eternal flame for the soul of ReMA, of blessed memory" is situated at the left side of the Holy Ark, while at its right a reconstructed plaque commemorates the place where Rabbi Moshe Isserles used to pray.