Rena N. D'Souza (born January 22, 1955) is a clinician-scientist and Director of the National Institute of Dental and Craniofacial Research.

She was formerly the assistant vice president for academic affairs and education for health sciences at the University of Utah where she was also a Professor of Dentistry in the School of Dentistry and a Professor of Neurobiology and Anatomy in the School of Medicine.

[1] D'Souza's research interests center on tissue engineering and dental care, working with tooth stem cells to develop a method to re-grow the living tissue and eliminate the need for root canals.

[5] In June 2020, D'Souza became the inaugural Ole and Marty Jensen Endowed Chair, which was established to enable further innovations in tissue engineering for dental and craniofacial research.

[7] In August 2020, D'Souza was selected as the National Institute of Dental and Craniofacial Research's ninth director, replacing Martha Somerman, who served from 2011 to 2020.