He often painted proletarian neighborhoods of the industrial port city of Livorno, as well as genre and cabaret scenes.
He did not attend a formal academy, although he was said to have learned from Guglielmo Micheli, and was a member of the Gruppo Labronico of painters that met in the Caffè Bardi in Livorno.
In Paris, he encountered the vibrant bohemian circles of artists, including Amedeo Modigliani, and the works of Toulouse Lautrec.
[2] A "Mostra Antologica Renato Natali" was organized in 1968 by the Casa Comunale della Cultura a Livorno, and curated by Piero Caprile with a monograph by Aldo Santini.
[3] Among the titles of his works are: Dramma, Rissa, Ombra, Chiacchiera, Ombre e Luci, Veglione, Mascherata, Sera estiva, Musica Rusticana, Rotonda, Via dei Mulini a Vento, Voltina, Lazzeretto di Ardenza, and Baruffa[4]