However, at a time when production technologies were relatively inflexible, the need to assemble differently configured engine bays on a single production line, along with the supplementary inventory requirements imposed both on Renault and on the dealership network, did compromise the Renault 21's profitability.

[2][3] First unveiled on 20 November 1985 and officially launched in February 1986, the R21 gave Renault a new competitor in this sector after eight years of the R18, which was declining in popularity after a very strong start to its commercial life.

The car was revamped considerably in May 1989, both technically and aesthetically – the new sleeker outward appearance was similar to the also recently revamped Renault 25, and a liftback body style was also added to the range (which soon became more popular than the saloon in France) along with a sporty 2.0 L Turbo version.

The Nevada wagons received four-wheel-drive in the eight-valve 2.0 and in the naturally aspirated 2.1 Diesel, as the 12-valve and the turbo were not available with this body style.

[6] At the 1989 Frankfurt Motor Show the fuel injected 2.2i model was introduced, originally reserved for the German market (being a different model than the earlier 2.2s built for the US) where insurance and tax regulations suited larger engines with less peak power.

[5] The Renault 21 liftback and saloon petrol models ceased production in the beginning of 1994, following the launch of the all new Laguna liftback, but the diesels and the Nevada/Savanna remained on the market, until their replacement Laguna variants were launched (end of 1994 for the diesels, and end of 1995 for the Nevada/Savanna).

The R21 was built in Argentina at the Renault facility in Santa Isabel (Córdoba Province) from late 1988 until early 1996.

The entry level model was simply the 21 (1.7 L), the mid-range trim was called 21 Manager (1.7 L, 90 PS), and at the top-of-the-line sat the 2.0-liter fuel injected "Concorde."

[7] However, the car was only on sale for a few months in 1987 before Renault sold its investment in American Motors Corporation (AMC) to Chrysler.