Regarded as one of Italy's greatest-ever players, he was known for his excellent technique, dribbling skills, and his accuracy from penalty kicks, despite being a defender.

As a ball-winning full-back, he was known for his strength, tackling ability, anticipation, and his organisational skills on the left flank, and was also capable of playing in the centre or in midfield.

[2] Due to his class and playing ability, he was given the nickname "Il Figlio di Dio" (The Son of God) by the Milan fans.

[2] De Vecchi is the youngest official player to feature in a match for the Italy national team at 16 years, three months and 23 days, making his international debut as a substitute on 26 May 1910, in a 6–1 away defeat to Hungary.

[2][8] Following his retirement as a manager, De Vecchi worked as a journalist for La Gazzetta dello Sport.