Repression of heat shock gene expression (ROSE) element

The ROSE element is an RNA thermometer that negatively regulates heat shock gene expression.

During heat shock however, the structure changes freeing the ribosome binding site and allowing expression to occur.

[4] ROSE1 is found in Bradyrhizobium japonicum whereas ROSEAT2 is a closely related element from Agrobacterium tumefaciens.

[4] All ROSE elements contain a characteristic 'bulged G' opposite the Shine-Dalgarno sequence binding site, without this nucleotide the RNA thermometer loses its temperature-sensitivity.

[5] Expression of the heat shock protein IpbA in species of Pseudomonas is controlled by a ROSE-type RNA thermometer.

A representation of the 3D structure of the microROSE RNA. This derived from a solution NMR structure of the microROSE element. [ 1 ]