The film stars del Toro in the lead role, alongside Justin Timberlake, Alicia Silverstone, Eric Bogosian, Ato Essandoh, Domenick Lombardozzi, and Michael Pitt.

Will Grady finds his girlfriend Summer Elswick brutally murdered in a rural Maine house that they had been showing for sale as realtors.

Eli shows up at his house at night and gives him a flash drive with evidence that Summer was caught up in a scheme by the Gradys to launder drug money.

Tom later arrives at Eli's house and finds him missing with his kitchen scrubbed clean and an empty bleach bottle left behind.

Marty excuses himself to go to the bathroom, and Allen pleads with Tom to leave to save his life, before going upstairs, where Wally fatally shoots him.

On August 26, 2021, Netflix was set to produce the crime thriller script Reptile with music video director Grant Singer set to make his directorial feature film debut and with Molly Smith, Trent Luckinbill, Seth Spector, Thad Luckinbill, Benicio Del Toro, and Rachel Smith as the film’s producers.

[2] On September 30, 2021, Alicia Silverstone, Michael Pitt, Ato Essandoh, Frances Fisher, Eric Bogosian, Domenick Lombardozzi, Karl Glusman, Matilda Lutz, Owen Teague, and Catherine Dyer were cast in the film.

[3] On October 14, 2021, Mike Pniewski, Thad Luckinbill, Sky Ferreira, James Devoti, and Michael Beasley were cast in the film.

The website's consensus reads: "Strong work from Benicio del Toro and Alicia Silverstone isn't enough to make up for Reptile's convoluted and ultimately underwhelming story.

[12] On October 10, 2023, Reptile earned the #1 spot for English language films around the world on Netflix with 19.9 million views for the week, and on October 17, 2023, Reptile earned the #1 spot for English language films around the world on Netflix with 14.2 million views.

On October 19, 2023, The Wrap reported that for the third consecutive week Reptile was the most-watched title of all films and tv shows across any streaming service.