Rescue is an unincorporated community in Isle of Wight County, Virginia, United States.

Rescue is located on Jones Creek near its confluence into the James River, 4 miles (6.4 km) east-northeast of Smithfield.

Located on the east side of the Jones Creek, approximately one-half of a mile from its mouth, it became a thriving harbor and a commercial dock for watermen engaged in fishing and oystering.

Within the Village Center are homes, two marinas, a restaurant, post office, and a former community center (originally this building was the old Rescue school constructed in 1925, which ultimately served as the meeting place for the Rescue Community League and Ruritan Club).

Historically, Boundary Road has always been the dividing line separating the Rescue community from the Carrollton area.