The Machín–Ramos Residence (Spanish: Residencia Machín–Ramos) is a historic late 19th-century house located in San Lorenzo Pueblo, the administrative and historic center of the municipality of San Lorenzo, Puerto Rico.

The Machín family originated from the island of Fuerteventura in the Canary Islands, relating to the Isleño or Canarian vernacular architectural style that inspired this type of residence throughout 18th and 19th-century Puerto Rico.

Today it functions as a house museum and as the headquarters of the Municipal Department of Art, Culture and Tourism of San Lorenzo (Departamento de Arte, Cultura y Turismo de San Lorenzo).

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