Written by vocalist, guitarist and pianist Matthew Bellamy, it was released as the third single from the album, following "Uprising" and "Undisclosed Desires", on 22 February 2010.

In February 2010, Muse had uploaded a picture puzzle of "Resistance" artwork on their official Facebook page.

The song was also released as downloadable content for the music video game Guitar Hero: Warriors of Rock.

The same week resulted in "Resistance" climbing to the number one spot on the UK Rock Chart, as well.

Touring members: Morgan Nicholls (2004, 2006–2022), Daniel Newell (2006–2008), Alessandro Cortini (2009), Dan Lancaster (2022–present)