[22] One review found limited evidence that resveratrol lowered fasting plasma glucose in people with diabetes.

One review concluded that resveratrol had no effect on neurological function, but reported that supplementation improved recognition and mood, although there were inconsistencies in study designs and results.

[27] A 2022 meta-analysis provided preliminary evidence that resveratrol, alone or in combination with glucose and malate, may slow cognitive decline in Alzheimer's disease.

[32] As of 2015, many specific biological targets for resveratrol had been identified, including NQO2 (alone and in interaction with AKT1), GSTP1, estrogen receptor beta, CBR1, and integrin αVβ.

[41][42] UV irradiation to cis-resveratrol induces further photochemical reaction, producing a fluorescent molecule named "Resveratrone".

[43] Trans-resveratrol in the powder form was found to be stable under "accelerated stability" conditions of 75% humidity and 40 °C in the presence of air.

[49] The grapevine fungal pathogen Botrytis cinerea is able to oxidise resveratrol into metabolites showing attenuated antifungal activities.

Adverse effects resulted mainly from long-term use (weeks or longer) and daily doses of 1000 mg or higher, causing nausea, stomach pain, flatulence, and diarrhea.

[52] A 2018 review of resveratrol effects on blood pressure found that some people had increased frequency of bowel movements and loose stools.

[16] Resveratrol is a phytoalexin, a class of compounds produced by many plants when they are infected by pathogens or physically harmed by cutting, crushing, or ultraviolet radiation.

[6][55] Though its extraction (i.e. from wood chips or other sources) during artificial ageing, resveratrol is added in red wines to improve the color and sensory properties.

[57] Most US supplements of resveratrol are derived from the root of Reynoutria japonica (also called Japanese knotweed, Hu Zhang, etc.

[53][58][59][60] In 2004, Harvard University professor David Sinclair co-founded Sirtris Pharmaceuticals, the initial product of which was a resveratrol formulation.