Its relative importance in mediating myelin inhibition in vitro and in vivo is currently under intense investigation, since this protein might be a good drug target for treatment of various neurological conditions such as spinal cord injury and stroke.

NgR is a membrane protein that, when bound to neurite outgrowth inhibitor (Nogo), inhibits cell growth through the activation of rho kinase (ROCK).

Through a variety of experimental procedures Wang et al.[7] were able to identify the biochemical relationship between NgR and p75.

Completing binding assays and co-immunoprecipitations revealed that p75 and NgR were not bound to each other through the cellular membrane.

The work of Kaplan and Miller[8] shows that there is an interaction between the p75/NgR receptors and Rho GDP dissociation inhibitor (Rho-GDI).

Rho-GTP, a Rho GTPase, then activates ROCK which phosphorylates other proteins which inhibit neurite outgrowth.

[11] This function of NgR is of particular interest to the study of visual disorders that may result from imbalanced input during the critical period, such as amblyopia.