Gangreen was perplexed at being defeated by "Puberty Love", the worst song ever created, and says that this time music will aid, rather than hinder him.

With his tomato commandos, Gangreen seeks to break out his imprisoned ally Jim Richardson and install him as President of the United States.

The plot breaks the fourth wall as the characters relate to the audience that the production has run out of money.

Arriving home, Chad finds Tara consuming plant food—they both scream and she runs away, only to be kidnapped by Igor and returned to Dr. Gangreen.

They find the machine can create a wide range of people depending on the music used, including more beautiful women (of great interest to Matt) but they do not get Tara back.

Outside the locked door they hear FT, to whom they pass a message to deliver to Wilbur, who gathers a team of heroes from the first film to rescue the captives.

He and Igor leave with a captive Tara to raid the prison and start Dr. Gangreen's plan for world domination; Wilbur and his team rescue Chad and Matt.

Chad and Tara ride off into the sunset with the blessing of Wilbur, and Matt dismantles Dr. Gangreen's transformation machine.

[6] The art for the poster was created by then illustrator now portrait painter, David R. Darrow, now living in San Jose, California.

JoBlo.com reviewer Jason Adams wrote, "The zany, self-referential style lends itself to an unending stream of gags, and overall more jokes work than don't.

"[10] DVD Talk reviewer Adam Tyner wrote, "Its hyper-meta sense of humor was years (maybe approaching decades) before its time.

Return of the Killer Tomatoes doesn't just break the fourth wall; it grinds it into a fine powder, mixes it with some hardwood mulch, and lets all manner of comedy and humor blossom from there".

[11] Chris Coffel, writing for Bloody Disgusting, in review of the Blu-ray edition of the film, wrote, "Return of the Killer Tomatoes has so many great jokes and little tidbits that you can’t possibly catch them in one viewing.

"[12] Anthony Arrigo, reviewing the same edition for Dread Central, called the film a "zany riot.

[...] Think the output of Zucker/Abrams back in their heyday, add a dose of Mel Brooks’ humor, and that's the direction for this sequel to the equally absurd Attack of the Killer Tomatoes (1978).