Reuben Sanford (December 3, 1780 Woodbury, Connecticut – May 19, 1855 Columbus, Ohio) was an American politician from New York.
About 1800, he removed to that part of Jay, New York which was separated in 1821 as the Town of Dansville, and renamed Wilmington in 1822.
He was a major of an independent battalion drawn from Essex County, New York, Sanford's Battalion, which was set off from the New York State 9th Regiment of Infantry during the War of 1812.
He and his men fought in the Battle of Plattsburgh in September, 1814.
He was buried at the Green Lawn Cemetery, Columbus, Ohio.