Reuben Webster Millsaps (May 30, 1833 - June 28, 1916) was an American businessman, financier and philanthropist.

Millsaps was born on May 30, 1833, into a farming family in Pleasant Valley, Copiah County, Mississippi, one of nine siblings.

Reuben Millsaps attended Indiana Asbury College, now known as DePauw University, and Harvard University Law School, where he earned a law degree.

After returning from the war he pursued a successful career in business and finance.

[citation needed] In 1890, Millsaps donated US$550,000, which was matched by contributions from Mississippi's Methodist community, for the creation of "a Christian college within the borders of our state".