Commonly referred to as rhabdoid features, the maturing rhabdomyoblast will likely exhibit low levels of eosinophilic cytoplasm in proximal distances to the nucleus.
In the concluding phase of differentiation, the white blood cell rich cytoplasm appears bright and exhibits cross-striation.
[9][10][11] The earliest written acknowledgment of cancer took place in 1600 BC in Edwin Smith Papyrus, an ancient Egyptian medical treatise.
[12] The type of treatment used is determined by a combination of factors, including recommendations provided by health professionals, patient preferences, and biological properties of the cancer.
[14] In clinical settings, the emergence of post-chemotherapy rhabdomyoblast differentiation in cases of pediatric embryonal rhabdomyosarcoma is an encouraging prognosis, as it potentially signifies the tumor's increased response to the provided therapy.
[14] Outlier case reports have been presented, including the aggressive prognosis of embryonal rhabdomyosarcoma and the simultaneous development adipocyte-like cells.
[14][15] Other favorable prognosis factors following target therapies exist and may serve as a more reliable indicator until sufficient data regarding rhabdomyosarcoma cases are available.
[14] Medical professionals have suggested that well defined rhabdomyoblasts with a low mitotic index serve as a marker to terminate additional treatment regimens.
[3] In general, the severity of rhabdomyosarcomas vary based on the tumor location and other factors; the five year survival rates rang from 35% to 95%.
[5][17] Concerns arise due the similarities between these two sarcomas; rhadbodomyofibrosarcomas have a more aggressive and costly prognosis than that of fibrosarcomas through distant metastasis and recurrence.
[5] Its name was coined due to the tumor's ability to promote the growth of limbs on the backs' of triton salamanders in animal transplant models.
[5] The quantity of rhabdomyoblasts present throughout the stroma is variable, with defining characteristics being eosinophilic rich cytoplasm and an unusual polygonal-like shape.
[5] Microscopically, the cytoplasmic content makes the rhabdomyoblast easily identifiable at low power due to its sharp contrast with the pale background of Schwannian cells.
[5] The differentiation of rhabdomyoblasts in malignant triton tumors from that of rhabdomyosarcomas may be difficult; this difficulty can be further compounded by the association of patients with neurofibromatosis 1 and increased risk of rhadbodomyofibrosarcoma.
[5] The development of malignant ectomesenchymomas are still not fully understood; it has been suggested, due to consistent genetic abnormalities, that the neoplasm may be a variant embryonal rhabdomyosarcoma.
[5] Clinically, its presence in children induces respiratory distress, a non-productive cough, fever, and chest pain.
[5] In the type 1 categorization, the exterior region of the cyst may contain rhabdomyoblastic differentiation in addition to the early stages of abnormal tissue growth.
[5] The mesenchymal portion may exhibit elongated rhabdomyoblasts in sheets or clusters; this appearance is a product of the common rhabdomyosarcomatous proliferation.