As a player, Wilkinson made over 180 appearances for the Canadian national team and won Olympic bronze medals in 2012 and 2016.

She played soccer for the Quebec provincial team from 1997 to 1999 and was named most valuable player in 1999 after helping the club to the silver medal at the nationals.

[citation needed] She began playing for Team Strømmen of the Toppserien (Norwegian league) in autumn 2005 and maintained her relationship with the club over the course of eight seasons.

[citation needed] In 2015, Wilkinson joined Portland Thorns FC of the National Women's Soccer League through NWSL Player Allocation.

[20] In February 2021, Wilkinson was appointed as assistant manager of the England women's national team with Hege Riise in charge.

[22] In November 2021, Wilkinson was named head coach of Portland Thorns FC of the National Women's Soccer League (NWSL).

[23] She led the team to a second-place finish in the regular season, followed by winning the 2022 NWSL Championship 2–0 over the Kansas City Current.