Route 401 is a 2.50-mile (4.02 km) state highway in East Greenwich, Rhode Island, United States.

Route 401 begins at an intersection with Route 2 (County Trail) / Division Street in East Greenwich, and begins east along a four-lane suburban road.

Route 401 continues east and crosses the Maskerchugg River, then curves southeast and crosses Dark Entry Brook.

It then reaches its eastern terminus at US 1 (Main Street) / Rocky Hollow Road just west of Greenwich Cove.

[1] The entire route is in East Greenwich, Kent County.