Garrone began his acting career in 1949 and attended the Silvio d'Amico National Academy of Dramatic Arts.

He also worked in several theatre productions alongside other actors such as Vittorio Gassman, Diana Torrieri and Elena Zareschi.

Garrone often portrayed characters with persuasive, polite personalities in a variety of B movie comedies, spaghetti-westerns and horrors.

One of his most popular television roles was on Un medico in famiglia in which he portrayed Nicola Solari.

He was internationally renowned for providing the Italian voice of Lots-O'-Huggin' Bear in Toy Story 3.