Since 2003, he has worked for NFL Network as a host of various pregame, halftime, and postgame shows and doing occasional play-by-play.

He was then a sports anchor and reporter at KRCR-TV in Redding, California, from 1994 to 1996, and also worked in television as the Medill News Service's Washington correspondent (1994).

He was part of a duo with Stuart Scott, where he became well known for his humor, most notably his impressions of Atlanta Braves broadcaster Skip Caray, and provided interviews during the Home Run Derby.

Among Eisen's notable achievements while at ESPN was breaking the news of St. Louis slugger Mark McGwire's retirement from baseball in 2001 on SportsCenter.

Eisen hosts his nationally syndicated sports talk radio show with Chris Brockman, Michael Del Tufo, and TJ Jefferson.

In November 2012, Eisen's first Thanksgiving Special aired on the NFL Network with a variety of celebrity guests talking mostly sports and current events.

[8] Eisen turned his annual sprint into a charitable campaign "#RunRichRun" which raises money for St. Jude Children's Research Hospital.

The show was broadcast live from DirecTV's El Segundo, California Studios on Audience Network[11] and NFL Now.

[17] Eisen was the host of the TNT original reality series, The Great Escape, which debuted on June 24, 2012, and was cancelled in October 2012.

In February 2018, Eisen co-hosted, with Rebecca Romijn, The American Rescue Dog Show on The Hallmark Channel.

[19] In 2022, Eisen was as guest star in five episodes of the Disney TV series The Mighty Ducks: Game Changers.

In 2024, Eisen and his show were featured by Jerry Seinfeld and Colin Jost in a comedy bit on Saturday Night Live's Weekend Update.