[citation needed] After college, Caruso began his career with PriceWaterhouse & Co in Philadelphia as a certified public accountant.
In 1989, Caruso founded Integra LifeSciences and took it public in August 1995, listing on the National NASDAQ Market under the symbol “IART”.
This company went public on the NASDAQ and London Stock Exchange before being acquired in 1999 by Advanced Voting Solutions, Inc. Caruso served on various boards of other organizations including First Sterling Bank, Advanced Voting Solutions, Inc., American Capital Mutual Funds, Museum of the American Revolution and the Medici Archive Project.
Caruso was also an advisor to Quaker BioVentures, a venture capital firm, and Infegy, a social media analytics company.
In 2006, Caruso received the prestigious Ernst & Young and Kauffman Foundation sponsored Greater Philadelphia Entrepreneur of the Year Award for his work with Integra LifeSciences Corporation.