[3] In 2009, David-Caine set up his own comedy group, Four Screws Loose, along with Joseph Elliott (actor), Conan House and Thom Ford.

The group's style revolved around high energy routines, physical comedy and audience interaction[4] and garnered mostly positive reviews.

[5] David-Caine's first lead TV role came when he was cast as one half of the comedy double act Cook and Line on CBeebies' new pirate gameshow, Swashbuckle.

David-Caine was also selected as part of the core cast in BAFTA-winning comedy sketch show, Horrible Histories.

Other notable work includes BBC Three sitcoms Dead Air (as best friend, Hardip) and People Just Do Nothing (as Chabuddy G's boss, Sam).