While a federal prosecutor, Myers prosecuted a wide variety of crimes including counterfeiting, narcotics, and firearms offenses.

He has been nominated to the seat vacated by Malcolm Jones Howard, who assumed senior status on December 31, 2005.

[5] Myers was nominated to a seat that had been vacant since December 31, 2005, at the time was the longest federal judicial vacancy.

[1] In 2022, Myers concluded that a Civil War amnesty law passed by Congress in 1872 essentially repealed the 14th Amendment's "disqualification clause," which prohibited officeholders from returning to elected positions if they supported an insurrection.

[13] Myers agreed that the Amnesty Act of 1872 applied not only retroactively to Confederate officials, but also in perpetuity regarding future rebellions.

This interpretation was later rejected by an appeals court, which ruled that this law applied only to people who committed "constitutionally wrongful acts" before 1872.