He studied under Thomas Sommers, a Catholic schoolmaster at Grange-over-Sands, Lancashire, and was subsequently sent to the English College at Douay.
Returning to Douay he was ordained a priest in 1607, and in the following year was sent on the English mission.
In 1619 he came back to the mission, and was instrumental in conversions among major families in Lancashire and Yorkshire to the Roman Catholic faith.
Huddleston left several pieces in manuscript, which appear to have been lost, and a Short and Plain Way to the Faith and Church, published by his nephew, Father John Hudleston, London, 1688; reprinted in the "English Catholic Library" vol.
Charles II, while concealed at Moseley after the defeat at Worcester, read this treatise in manuscript, and declared that he had seen nothing clearer upon the subject.