[1] Mepranum made his professional debut on August 31, 2005, defeating fellow Filipino boxer Leovimil Florentino by KO in Magpet, Cotabato (del Norte), Philippines.
The Filipino boxer won the WBO Oriental flyweight title on June 14, 2006 against previously unbeaten Joma Funda.
Mepranum suffered his first loss on September 14, 2007, against Thai boxer Denkaosan Kaovichit at the Potawattana Saenee School, Ratchaburi, Thailand.
[2] On March 12, 2010, Mepranum fought against Mexico's unbeaten Hernan "Tyson" Marquez (27-0; 20 KO) at the Gaylord Hotel in Grapevine, Texas, United States.
In June 2010, Mepranum fought for the vacant WBO Flyweight title relinquished by Argentina's Omar Andrés Narváez.