He played college football for the Notre Dame Fighting Irish and was selected by the Seattle Seahawks with the second overall pick of the 1993 NFL draft.
He spent the remainder of his career with the New York Jets, San Francisco 49ers, Oakland Raiders, and Detroit Lions, mostly as a backup.
Mirer posted 3,973 yards and 30 touchdowns in his senior year, 2nd most in national prep history, and eclipsing Jeff George's Indiana High School passing records.
Mirer attended the University of Notre Dame from 1989 to 1992, accumulating a 29–7–1 record as starter – including 3 bowl games.
He began his tenure serving as backup to Tony Rice, then took the reins of the Notre Dame offense in 1990 and led the team to the Orange Bowl.
In 1991, Mirer set the single season touchdown record with 18 and was named co-MVP with teammate Jerome Bettis leading Notre Dame past Florida in the 1992 Sugar Bowl.
Entering the 1993 Draft, he was hyped as the next Joe Montana, who also played college football at Notre Dame and was similar in stature.