She voiced Megumin in KonoSuba, Emilia in Re:Zero, Takagi in Teasing Master Takagi-san, Mash Kyrielight in Fate/Grand Order, Mirai Asahina/Cure Miracle in Witchy Pretty Cure!, Yuzuriha in Hell's Paradise: Jigokuraku, Sumi Sakurasawa in Rent-A-Girlfriend, and Ai Hoshino in Oshi no Ko.
[4] While continuing with her lessons, she became part of the voice actor unit Anisoni∀, alongside Reina Ueda, Chiyeri Hayashida and Kayoto Tsumita.
In 2013, she played background or supporting roles in each series, such as Stella Women's Academy, High School Division Class C3, Driland and Aikatsu.
[14] She also voiced Noct Leaflet in Undefeated Bahamut Chronicle,[6] OL in Digimon Universe: Appli Monsters,[6] Mirai Asahina in Maho Girls PreCure!,[15] and Code Omega 00 Yufilia in Ange Vierge.
[17] She voiced Mash Kyrielight in the mobile phone game Fate/Grand Order, replacing Risa Taneda who had gone on hiatus earlier that year.
[18] In 2017, Takahashi reprised the role for the second season of KonoSuba, where she, Amamiya and Kayano performed the series' closing theme "Ouchi ni Kaeritai" (おうちに帰りたい, I Wanna Go Home).
In February 2021, Takahashi announced her debut as a solo singer under A-Sketch/Astro Voice on April, along with the launch of her official fanclub, "Takaharitsu Riekoukou" (たかは私立りえ高校).