Her most notable roles include Pramanix in Arknights, Himawari Uzumaki in Boruto: Naruto Next Generations, Shinobu Kochō in Demon Slayer: Kimetsu no Yaiba, Leona in Dragon Quest: The Adventure of Dai, Kamisato Ayaka in Genshin Impact, Miyuki Shiba in The Irregular at Magic High School, Ryuu Lion in Is It Wrong to Try to Pick Up Girls in a Dungeon?, Yumeko Jabami in Kakegurui, Rui Komada in Komada: A Whisky Family, Yotsugi Ononoki in Monogatari, Yukino Yukinoshita in My Youth Romantic Comedy Is Wrong, As I Expected, Yamato in One Piece, Ruby Rose in RWBY: Ice Queendom, Shōko Nishimiya in A Silent Voice, and Yor Forger in Spy × Family.

In 2007, she made her anime debut and landed her first major role as Momoka Kawakabe, the main heroine in Touka Gettan.

[7] Hayami is known for her singing mainly through her work performing anime and character theme songs, such as Kaede Takagaki in The Idolmaster Cinderella Girls franchise.

The title song was used as opening theme for anime television Snow White with the Red Hair in which she voiced Shirayuki.

The song "Sono Koe ga Chizu ni Naru" is used as the opening theme for the second season of Snow White with the Red Hair.