Rieti railway station is located at the center of the city, just outside the medieval walls that enclose the historic city centre on its north side, and south of modern residential neighborhoods Regina Pacis, Madonna del cuore and Micioccoli.

The station started operating on 30 October 1883, when the Rocca di Corno-Terni part of the Terni–Sulmona railway was opened.

Upon construction, a 200 metres stretch of the nearby medieval walls were demolished, in order to create a new, large passage in the walls, so that arriving passenger could easily access the city centre.

[2] Trains stopping in the station are regional trains running from Terni to L'Aquila, operated by Ferrovia Centrale Umbra company, on behalf of Trenitalia, with ALn 776 diesel multiple units.

[4] In addition, in recent years a direct train from Rieti to Rome, at early morning, and a direct train from Rome to Rieti, in the late evening, were introduced; both train pass through Terni, travel on the Ancona–Orte railway, reach Orte and then travel on the Florence–Rome high-speed railway taking approximately 1 hour and 40 minutes.