Rio Grande Blood is the tenth studio album by American industrial metal band Ministry, released in 2006.

The album is the second installment in the band's anti-George W. Bush trilogy, preceded by 2004's Houses of the Molé and followed by 2007's The Last Sucker.

[7][8] Just like Houses of the Molé, Rio Grande Blood contains very political lyrics, making frequent allusions to the George W. Bush administration.

The album also contains allegations of the Bush administration complicity in the September 11 attacks in the track "Lieslieslies," which contains audio samples from the conspiracy documentary series Loose Change.

Jourgensen ranks Rio Grande Blood as his second-favorite Ministry album, saying that not only he liked the songs but he had a good time working with Paul Raven and Tommy Victor.