The 1550 MWe Economic Simplified Boiling Water Reactor (ESBWR) was the selected design.

The Nuclear Regulatory Commission defines two emergency planning zones around nuclear power plants: a plume exposure pathway zone with a radius of 10 miles (16 km), concerned primarily with exposure to, and inhalation of, airborne radioactive contamination, and an ingestion pathway zone of about 50 miles (80 km), concerned primarily with ingestion of food and liquid contaminated by radioactivity.

[10] The 2010 U.S. population within 10 miles (16 km) of River Bend was 23,466, an increase of 11.1 percent in a decade, according to an analysis of U.S. Census data for msnbc.com.

[11] The Nuclear Regulatory Commission's estimate of the risk each year of an earthquake intense enough to cause core damage to the reactor at River Bend was 1 in 40,000, according to an NRC study published in August 2010.

[12][13] Unlike the Waterford Nuclear Generating Station downriver in Hahnville, River Bend continued operation throughout Hurricane Katrina in 2005.