The road also designates the eastern boundary of the Santa Lucia Highlands AVA and accesses many of the resident wineries contributing to local enotourism business.

The earliest grape plantings in the region, however, were in the 1790s, with the arrival of the Spanish missions in California.

The hot climate of the Salinas Valley produces good Syrahs and the foggy nights are ideal for Chardonnay, Pinot Noir and other cool-climate varietals.

[8][9] They are perched on the eastern flank of the Santa Lucia Highlands with great views overlooking fertile valley farmlands.

[10] The River Road Wine Trail features wineries from three distinct growing regions: Monterey, Arroyo Seco and the Santa Lucia Highlands.