The river generates a large income for the local borders region, attracting anglers from all around the world.

[4] A doubtful proposal is that the name is derived from a non-Celtic form of the Indo-European root *teuha- meaning "swell, grow powerful".

Eastwards from the settlements on opposing banks of Birgham and Carham it forms the historic boundary between Scotland and England.

"Annan, Tweed and Clyde rise oot the ae hillside" is a saying from the Border region.

[8] As of 2024[update], work is in progress on the development of a 113-mile (182 km) walking and cycling route following the length of the river from Moffat to Berwick-on-Tweed.