It rises on Comb Fell in the Cheviot Hills.

Its tributaries include Wooler Water, which originates in the Cheviots, and the River Glen in Glendale.

It meets the Tweed a mile to the west of Twizell Bridge, 4 km downstream of Coldstream.

According to local folklore: Recent environmental projects have included an attempt to conserve the native brown trout.

This article related to a river in England is a stub.