Guillory handled pencils, inks, and colors, garnering him the 2010 Harvey Award for best new talent;[2] Guillory would illustrate the story arcs Taster's Choice, International Flavor, Just Desserts, Flambé, Major League Chew, Space Cakes, Bad Apples, Family Recipes, Chicken Tenders, Blood Puddin’, The Last Suppers, Sour Grapes, and Outer Darkness/Chew over the course of the series.
[8] Instead of pursuing more work-for-hire jobs after Chew ended in 2016, Guillory opted to launch a new creator-owned science fiction series Farmhand at Image Comics.
"[9] The series, written, penciled and inked by Guillory with colors by Taylor Wells, tells the story of a "body farmer" who grows human organs.
[12] Guillory said the initial response he received from readers was surprise; they had expected the story to be pure humor and were shocked to discover the characters had real depth.
[13] In April 2022, Guillory was reported among the more than three dozen comics creators who contributed to Operation USA's benefit anthology book, Comics for Ukraine: Sunflower Seeds, a project spearheaded by IDW Publishing Special Projects Editor Scott Dunbier, whose profits would be donated to relief efforts for Ukrainian refugees resulting from the February 2022 Russian invasion of Ukraine.